Fallon and Curtis Skewer Fielder and Holmes in Tonight Show Sketch

A late-night sketch on Wednesday night mocked two figures associated with modern media skepticism.

Jimmy Fallon adopted the mannerisms of Nathan Fielder for the cold open. Jamie Lee Curtis appeared as Elizabeth Holmes. The pair parodied A24’s documentary “You Can See Everything.” The film opened in theaters on Oct. 16 and has grossed $45.1 million domestically. Critics and audiences have responded favorably to the picture. Fielder and co-director Lance Oppenheim spent more than three years working on the project. The documentary examines the Theranos founder in the month before she began an 11-year prison sentence for defrauding investors.

In the sketch, Fallon questioned Curtis about her true intentions for appearing on the program. Curtis, wearing a blonde wig and staring directly into the host’s eyes, replied in a voice reminiscent of Holmes. She stated, “Of course I do. I love talking to you.” Fallon pressed her on whether she was there solely to promote her new show, “Newlyweds.” Curtis claimed she was engaging with him “as a human being.” She added, “Why would I deceive you? There’s no reason for me to do that. There’s nothing for me to deceive you on.”

Fallon concluded the interaction by asking if she was being genuine. Curtis answered, “I’m always being real.” After Fallon walked away, she dropped the character and shouted a profane remark at him. The segment served as a promotional vehicle for “Newlyweds,” a new NBC sitcom that premiered on Oct. 23. The series stars Téa Leoni and Tim Daly. Its logline describes it as a later-in-life love story about a free-spirited woman and a buttoned-up professor who marry impetuously after a whirlwind courtship.

Curtis co-created the show with Gail Lerner. She will appear in a recurring guest star role. Lerner was fired from the series earlier this month over “creative differences.” When the news broke, Lerner called the experience of working on the show “the most joyous TV experience of my life.”